| American League 2021 | |||||||||||||||||
| note: Inter league games you will play as the visiting team and use their park. Only play the games on your schedule. | |||||||||||||||||
| Rotation | |||||||||||||||||
| Order | Date | NYY | Tor | Col | Bos | Cle | Det | SD | Atl | TB | CWS | Pit | Sea | Bal | LAA | Oak | |
| 1 | 1,2,3 | 1-Apr | Cle | NYY 0-3 | Tor | Col 2-1 | Bos | Atl | TB | CWS | Det | SD | Oak 2-1 | Pit 2-1 | Sea 1-2 | Bal 1-2 | LAA 1-2 |
| 2 | 4,1 | 8-Apr | Det | SD 1-1 | CWS | ATL 2-0 | TB | Pit | Sea | LAA 1-1 | Oak | Bal | Bos | Cle 2-0 | NYY 0-2 | Tor 2-0 | Col 2-0 |
| 3 | 2,3,4,5 | 13-Apr | Pit | Sea 2-2 | Bal | LAA 1-3 | Oak | NYY | Tor | Bos | Cle | Col | TB | Det 4-0 | SD 1-3 | CWS | Atl 2-2 |
| 4 | 1,2,3 | 23-Apr | SD | CWS | Atl | TB 3-0 | Det | Sea | Bal | Oak | Pit | LAA | NYY | Tor | Col 2-1 | Bos | Cle 1-2 |
| 5 | 4,1 | 30-Apr | Sea | Bal | LAA | Oak 2-0 | Pit | Col | Bos 1-1 | NYY | Tor | Cle | Det | SD | CWS 0-2 | Atl | TB 2-0 |
| 6 | 2,3,4,5 | 5-May | Tor | Col | Bos | Cle | NYY | TB | CWS | Det | SD | Atl | Sea | Bal | LAA 3-1 | Oak | Pit 0-4 |
| 7 | 1,2,3 | 14-May | Tex | Was | Cin | NYM 2-1 | SF | Mil | Phi | Stl | Min | KC | Hou | Mia | Cub 1-2 | LAD | AZ 3-0 |
| 8 | 4,1 | 21-May | Bal | LAA | Oak | Pit | Sea | Tor | Col | Cle | NYY | Bos | SD | CWS | Atl 1-1 | TB | Det 1-1 |
| 9 | 2,3,4,5 | 26-May | CWS | Atl | TB | Det | SD | Bal | LAA | Pit | Sea | Oak | Tor | Col | Bos 3-1 | Cle | NYY |
| End of 1st trimester |
12-15
|
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| 10 | 1,2,3 | 1-Jun | Col | Bos | Cle | NYY | Tor | CWS | Det | SD | Atl | TB | Bal | LAA | Oak | Pit | Sea |
| 11 | 4,1 | 8-Jun | Atl | TB | Det | SD | CWS | LAA | Oak | Sea | Bal | Pit | Col | Bos | Cle | NYY | Tor |
| 12 | 2,3,4,5 | 13-Jun | LAA | Oak | Pit | Sea | Bal | Cle | NYY | Col | Bos | Tor | CWS | Atl | TB | Det | SD |
| 13 | 1,2,3 | 23-Jun | Cin | SF | Was | Tex | NYM | KC | Min | Mil | Phi | Stl | LAD | Cub | AZ | Mia | Hou |
| 14 | 4,5,1 | 30-Jun | Oak | Pit | Sea | Bal | LAA | Bos | Cle | Tor | Col | NYY | Atl | TB | Det | SD | CWS |
| All Star Break July 3 - 9 | |||||||||||||||||
| 15 | 2,3,4 | 10-Jul | Bos | Cle | NYY | Tor | Col | SD | Atl | TB | CWS | Det | LAA | Oak | Pit | Sea | Bal |
| 16 | 1,2 | 17-Jul | Det | SD | CWS | Atl | TB | Pit | Sea | LAA | Oak | Bal | Bos | Cle | NYY | Tor | Col |
| 17 | 3,4,5 | 22-Jul | NYM | Cin | SF | Was | Tex | Phi | KC | Min | Stl | Mil | Cub | Hou | LAD | AZ | Mia |
| 18 | 1,2,3,4 | 29-Jul | Cle | NYY | Tor | Col | Bos | Atl | TB | CWS | Det | SD | Oak | Pit | Sea | Bal | LAA |
| End of 2nd trimester | |||||||||||||||||
| 19 | 1,2 | 4-Aug | Sea | Bal | LAA | Oak | Pit | Col | Bos | NYY | Tor | Cle | Det | SD | CWS | Atl | TB |
| 20 | 3,4,5,1 | 9-Aug | TB | Det | SD | CWS | Atl | Oak | Pit | Bal | LAA | Sea | Cle | NYY | Tor | Col | Bos |
| 21 | 2,3,4 | 18-Aug | Tor | Col | Bos | Cle | NYY | TB | CWS | Det | SD | Atl | Sea | Bal | LAA | Oak | Pit |
| 22 | 1,2 | 25-Aug | SD | CWS | Atl | TB | Det | Sea | Bal | Oak | Pit | LAA | NYY | Tor | Col | Bos | Cle |
| 23 | 3,4,5 | 30-Aug | Bal | LAA | Oak | Pit | Sea | Tor | Col | Cle | NYY | Bos | SD | CWS | Atl | TB | Det |
| 24 | 1,2,3,4 | 6-Sep | Col | Bos | Cle | NYY | Tor | CWS | Det | SD | Atl | TB | Bal | LAA | Oak | Pit | Sea |
| 25 | 1,2 | 15-Sep | Oak | Pit | Sea | Bal | LAA | Bos | Cle | Tor | Col | NYY | Atl | TB | Det | SD | CWS |
| 26 | 3,4,5 | 20-Sep | Atl | TB | Det | SD | CWS | LAA | Oak | Sea | Bal | Pit | Col | Bos | Cle | NYY | Tor |
| 27 | 1,2,3,4 | 28-Sep | Bos | Cle | NYY | Tor | Col | SD | Atl | TB | CWS | Det | LAA | Oak | Pit | Sea | Bal |
| End of 3rd trimester | |||||||||||||||||
| Final home record | |||||||||||||||||